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Morton neuromas, also known as interdigital or intermetatarsalneuromas, are focal areas of symptomatic perineural fibrosis around a common plantar digital nerve of the foot. The condition is thought to be due to chronic entrapment of the nerve by the intermetatarsal ligament.

The term neuroma is a misnomer because the abnormality is non-neoplastic and does not represent a true neuroma¹⁷. It may more correctly be known as Morton metatarsalgia. 

Morton neuromas most often occur in middle-aged individuals and are many times more common in women than men. Approximately 30% of asymptomatic middle-aged persons have radiologic findings of a Morton neuroma. 

Patients typically present with forefoot pain which radiates from midfoot to toes ⁵. Symptoms are often progressive and worsened by activity. The Mulder sign is a physical sign associated with Morton neuroma, which may be elicited while the patient is in a supine position. The pain associated with the neuroma, as well as a click, can be reproduced by squeezing the two metatarsal heads together with one hand, while concomitantly putting pressure on the interdigital space with the other hand.

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